10 Most Terrible and Deadly Rare Diseases in History

A cold, fever, runny nose, or headache is a variety of diseases that are easily treated so that the chances of survival are high. Differences with a number of deadly diseases that are also rare below. Not only does it make a shudder, because until now the modern medical world has not managed to find an effective antidote or treatment for these conditions. Here's a list of the deadliest diseases in the world.

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A variety of rare deadly diseases in the world

1. Noma (Cancrum oris)

Noma (cancrum oris) is an infection that causes the formation of boils in the mouth or on the genitals. The boils that can be seen with the naked eye can "move" into the body tissues until they do not appear again, causing defects in the body.

The survival expectation of this deadly disease is quite small. Nearly 90 percent of people with Noma eventually die from complications of the infection. Noma generally occurs in malnourished children in areas where sanitation and hygiene are lacking. This infection is most common in children between the ages of 2 and 5 years.

2. Mycetoma (Madura Foot)

Mycetoma is a chronic skin disease that causes swelling in the legs and eventually paralyzes. Mycetoma caused by fungi (Eumycetoma) or filamentous bacteria (Actinomycetoma) has another name "Madura foot" - eits, not from Madura in Indonesia, after all! Mycetoma was first identified in Madurai, India, in the mid-19th century

Mycetoma usually occurs in agricultural workers or in individuals who walk barefoot in dry and dusty conditions.

3. Complex Regional Pain Syndrome (CRPS)

CRPS is a disease that causes tremendous pain, which makes the sufferer experience chronic fatigue due to lack of energy. CPRS is caused by damage to the nervous system and central nervous system in the brain. The pain can be so damaging that it causes mental health problems, such as depression and anxiety disorders.

A person suffering from CRPS will feel his body feel as hot as burning and experience body piercing pain and a throbbing sensation. This can also cause numbness, swelling, joint pain, and insomnia.

4. Leprosy

Leprosy is a skin infection caused by the bacterium Mycobacterium leprae. Leprosy is found in Indonesia. Leprosy causes inflammation of the skin, eyes, nerves and respiratory tract so that it can eventually cause loss of body parts that look terrible and loss of vision.

The most common symptoms of leprosy are pale patches on the skin that are scattered randomly and gradually feel numb. Body parts that are infected will be lost to bacteria. Leprosy symptoms usually occur within three to five years after exposure to the M. leprae bacteria. Some people don't experience symptoms until 20 years later.

The time interval between contact with bacteria and the appearance of symptoms can be very long, making it difficult for doctors to determine the diagnosis of when and where leprosy initially infects. The difficulty of diagnosis is that treatment can be late, and ultimately fatal.

5. Filaria worms (Loa Loa worms)

Filarial worms are parasites that like to live in the eyes and are the second leading cause of blindness worldwide. Filarial worms do not only endanger eye health. If this worm enters other parts of the body, the sufferer can experience elephantiasis. Other potential symptoms include rashes, stomach aches, arthritis, and papules.

6. Vibrio vulnificus

These bacteria enter the body through raw shells, through open wounds, and jellyfish stings that can cause severe infections. This disease causes several symptoms including vomiting, severe diarrhea, dermatitis, and severe abdominal pain.

Not only that, Vibrio vulnificus also weakens the immune system, affects the liver and blood flow and can eventually kill if it does not get the right treatment. This condition occurs due to high temperatures and a decrease in salt levels on the beach which causes high pathogens.

7. Pica

Pica is an eating disorder characterized by eating behavior that is not normal, namely the desire to eat things that are actually not to be eaten. The most common pica is the desire to eat one of the following items: soil, chalk, matchstick, fiber cloth, paper, toothpaste, cigarette butts and cigarette ash, dry paint splinters, and glue.

Depending on the type of item you eat, Pica can cause severe infections in the organs and can be deadly. Pica usually starts in childhood and usually lasts only a few months. However, the possibility will be more difficult to deal with in children with disabilities.

8. Ossificans Progressiva (FOP) fibrodysplasia

Ossificans Progressiva (FOP) is a disorder caused by a genetic mutation that causes muscle tissue and the body's connective tissue, such as tendons and ligaments, to be replaced by solid bone gradually. This abnormal bone formation outside the original skeleton will gradually inhibit movement and make the sufferer look like a statue. This process is generally seen in early childhood, starting with the neck and shoulders, then down the body and into the legs.

FOP is caused by a genetic mutation, the ACVR1 gene. This gene is involved in bone growth and development which makes them mutate more.

9. Clarkson's disease

Systemic capillary leak syndrome is a rare disorder characterized by plasma leakage from blood vessels. This causes swelling. Symptoms begin with a sudden and unexplained increase in small blood vessels (capillaries). If left untreated, it can cause organ failure and death. This condition is also called Clarkson's disease.

10. Elephant man syndrome

This case initially occurred in a man from England in 1862. He experienced a change in skin texture that became thickened roughly, resembling elephant skin. This rare disorder is characterized by overgrowth of various organs and tissues of the body. The organs and tissues that are attacked by this disorder grow disproportionately with other body parts.

This overgrowth affects the size of the right and left sides of the body. The pattern of growth of excess organs or tissues varies greatly but can affect almost all parts of the body.